Multimorbidity in nephrotic syndrome

نویسندگان

چکیده

Nefrotický syndrom (NS) je charakterizován velkou proteinurií (nad 3,5 g/24 h), hypalbuminemií, generalizovanými otoky, hyperlipidemií a poruchami koagulace. Vedle primárních glomerulonefritid se vyskytuje u sekundárních glomerulopatií při diabetu, amyloidóze, systémových zánětlivých chorobách, onkologických onemocněních, poškození léky drogami, alergiích, závažných infekcích dětí jsou i formy vrozené. Nejčastější příčinou NS v dospělosti diabetes mellitus (DM). V současnosti DM 40 % selhání ledvin nemocných na dialýze. Z hlediska prevence proto věnována velká pozornost gliflozinům (SGLT2 inhibitory), které mají prokazatelně nefroprotektivní účinky. Glifloziny vedou k navození glykosurie, doprovázené současně natriurézou osmotickou diurézou. Účinnost gliflozinů snížení glykemie proporcionální úrovni glomerulární filtrace, zatímco efekty vázané natriurézu zachovány ve všech stadiích renální insuficience.

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ژورنال

عنوان ژورنال: Vnitr?ni? le?kar?stvi?

سال: 2023

ISSN: ['0042-773X', '1801-7592']

DOI: https://doi.org/10.36290/vnl.2023.028