Multimorbidity in nephrotic syndrome
نویسندگان
چکیده
NefrotickĂ˝ syndrom (NS) je charakterizovĂĄn velkou proteinuriĂ (nad 3,5 g/24 h), hypalbuminemiĂ, generalizovanĂ˝mi otoky, hyperlipidemiĂ a poruchami koagulace. Vedle primĂĄrnĂch glomerulonefritid se vyskytuje u sekundĂĄrnĂch glomerulopatiĂ pĹi diabetu, amyloidĂłze, systĂŠmovĂ˝ch zĂĄnÄtlivĂ˝ch chorobĂĄch, onkologickĂ˝ch onemocnÄnĂch, poĹĄkozenĂ lĂŠky drogami, alergiĂch, zĂĄvaĹžnĂ˝ch infekcĂch dÄtĂ jsou i formy vrozenĂŠ. NejÄastÄjĹĄĂ pĹĂÄinou NS v dospÄlosti diabetes mellitus (DM). V souÄasnosti DM 40 % selhĂĄnĂ ledvin nemocnĂ˝ch na dialĂ˝ze. Z hlediska prevence proto vÄnovĂĄna velkĂĄ pozornost gliflozinĹŻm (SGLT2 inhibitory), kterĂŠ majĂ prokazatelnÄ nefroprotektivnĂ ĂşÄinky. Glifloziny vedou k navozenĂ glykosurie, doprovĂĄzenĂŠ souÄasnÄ natriurĂŠzou osmotickou diurĂŠzou. ĂÄinnost gliflozinĹŻ snĂĹženĂ glykemie proporcionĂĄlnĂ Ăşrovni glomerulĂĄrnĂ filtrace, zatĂmco efekty vĂĄzanĂŠ natriurĂŠzu zachovĂĄny ve vĹĄech stadiĂch renĂĄlnĂ insuficience.
منابع مشابه
Simvastatin in nephrotic syndrome. Simvastatin in Nephrotic Syndrome Study Group.
BACKGROUND Hyperlipidemia of the nephrotic syndrome is a risk factor for the development of systemic atherosclerosis, but it also may aggravate glomerulosclerosis and enhance the progression of glomerular disease. HMG-CoA reductase inhibitors are effective in reducing cardiovascular morbidity and mortality. Whether they may influence the progression of glomerular disease is not clear. The Simva...
متن کاملExamine of Thyroid Function in Pediatric Nephrotic Syndrome; Tehran-Iran
Introduction In children with nephrotic syndrome, it is probable to determine a hypothyroid state because of thyroxine (T4), tri-iodothyronine (T3) and thyroid-binding globulin loss in presence of proteinuria. Objectives: To examine thyroid function in pediatric cases of nephrotic syndrome. Methods: In a cross-sectional study, from march 2010 to march 2012, thyroid function tests were performed...
متن کاملBone Mineral Density in Children with Relapsing Nephrotic Syndrome
AbstractBackground: Given the high relapse rate of disease in children with steroid dependent nephrotic syndrome and the osteoporotic effect of long periods of steroid therapy, this survey was performed to find the bone mineral status of these patients. Methods: Bone mineral density and content (BMD and BMC) were measured using Dual energy X-ray absorptiometry in 37 nephrotic children, six girl...
متن کاملSuccessful treatment of nephrotic syndrome in twin pregnancy: case report
Background: Nephrotic syndrome is a kidney disorder that is identified by signs of nephrosis, severe proteinuria, hypoalbuminemia, and edema. It is a component of glomerulonephrosis, in which different degrees of proteinuria may occur. The complications of this syndrome may include blood clots, infections, and high blood pressure. Essentially, decreased protein through the kidneys (proteinuria)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vnitr?ni? le?kar?stvi?
سال: 2023
ISSN: ['0042-773X', '1801-7592']
DOI: https://doi.org/10.36290/vnl.2023.028